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For some multiple myeloma patients, Carvykti cut risk of death by 45%
Johnson & Johnson and Legend Biotech’s CAR-T cell therapy Carvykti reduced the risk of death by 45% compared to standard of care at almost three years for a portion of multiple myeloma patients,...
View ArticleMeet this year’s Endpoints 11; J&J winds down cardiovascular and metabolic...
Welcome back to Endpoints Weekly, your review of the week’s top biopharma headlines. Want this in your inbox every Saturday morning? Current Endpoints readers can visit their reader profile to add...
View ArticleUpdated: Pfizer to further decrease stake in consumer health company Haleon
Pfizer has continued shrinking its ownership in the British consumer health company Haleon. The New York drugmaker sold 640 million shares, raising about $3.26 billion in gross proceeds, according to...
View ArticleJ&J pulls the plug on 340B rebate model changes opposed by government
Johnson & Johnson has called off plans to implement a new rebate model for 340B drug price discounts following threats from the federal government. While continuing to defend the legality of the...
View ArticleCalifornia's Gavin Newsom vetoes bipartisan PBM reform bill
California Gov. Gavin Newsom vetoed bipartisan legislation on Saturday that would have reformed pharmacy benefit managers in the state, prompting the bill’s author to call the decision “a massive...
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FDA pledges to take next steps on advisory committee changes
As the potential end of Robert Califf’s time as FDA commissioner nears, he and a key deputy are continuing to push forward with changes to the advisory committee process. In a Nature commentary...
View ArticleAppeals court rules in favor of FDA regulating certain stem cell clinics more...
A court ruling Friday will open the door to the FDA more tightly regulating stem cell clinics and a commonly-used stem cell mixture known as stromal vascular fraction (SVF) treatments. The ruling, made...
View ArticleFederal judge dismisses longstanding suit over Bristol Myers' $74B Celgene...
A New York federal judge dismissed allegations on Monday that Bristol Myers Squibb purposely delayed Breyanzi’s approval to avoid paying out $6.4 billion in contingent value rights. Judge Jesse Furman...
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IGM scraps oncology work to focus on autoimmune, loses three executives
IGM Biosciences will stop working in cancer and shrink its T cell engager pipeline to focus on autoimmune diseases, the California biotech said late Monday. Fred Schwarzer The company’s CEO, Fred...
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Metsera partners with Amneal to manufacture obesity drugs, and Clive Meanwell...
Obesity startup Metsera is getting a new manufacturing partner and a new CEO. On Tuesday, the well-funded startup announced that it would bring on specialty pharmaceutical and generics manufacturer...
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Ron Renaud's new obesity biotech, Kailera, has $400M to go straight to Phase 3
There’s major money behind efforts to speed the next significant obesity company to the market. First, it was Metsera, which launched in April with $290 million and a busy pipeline. Now it’s Kailera...
View ArticleShattuck Labs cuts CD47 program and 40% of workforce as it focuses on IBD drug
Shattuck Labs is laying off 40% of its workforce and discontinuing its CD47 program in acute myeloid leukemia and higher-risk myelodysplastic syndromes following disappointing early-stage data. The...
View Article23andMe CEO says she is no longer open to outside takeover offers
23andMe CEO Anne Wojcicki has said she is no longer open to considering other buyers for the company in a securities filing Monday, the latest in her monthslong attempt to take the turbulent genetics...
View ArticleCVS considers breaking up the company as investors urge turnaround — reports
Struggling healthcare giant CVS Health is considering breaking up the company, including separating its pharmacy and insurance businesses, as part of a strategic review, Reuters first reported late...
View ArticleCAMP4, preparing for IPO, announces partnership with BioMarin
Regulatory RNA startup CAMP4 Therapeutics has inked another collaboration deal as it prepares for an initial public offering. The Cambridge, MA-based startup has lined up a pact with BioMarin to create...
View ArticleGritstone bio’s stock dips after it shares more data from failed Phase 2...
Months after announcing the failure of a mid-stage trial for its personalized neoantigen vaccine in cancer, Gritstone bio reported more data that it plans to take to regulators. In the Phase 2 trial,...
View ArticleTargeting Novartis' Scemblix, Enliven lays out case for leukemia drug in...
Enliven Therapeutics released new Phase 1 data for its chronic myeloid leukemia program (CML) it hopes can eventually compete with Novartis’ Scemblix. The experimental therapy, called ELVN-001, was...
View ArticleBiohaven aims to raise $250M; Activist investor's stake in Galapagos exceeds 10%
Plus, news about IN8bio, Sanofi, Vicore Pharma, Cartherics, Zephyrm Bioscience, Tharimmune and Intract Pharma: Biohaven’s $250M offering: The move comes after Biohaven announced Monday that it started...
View ArticleJ&J and Bayer to lay off almost 300 staffers in New Jersey
Two pharma giants are cutting staff in New Jersey, with Johnson & Johnson and Bayer making new layoffs between now and the end of December. Johnson and Johnson plans to cut 231 employees, according...
View ArticleJudge keeps Amgen's $10.7B tax liability suit alive
A New York federal judge has denied Amgen’s motion to dismiss a class action lawsuit alleging the company misled investors about a potential $10.7 billion tax liability. Plaintiffs, led by a Detroit...
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