Teva to pay $750M to resolve Israel tax disputes
Teva has agreed to pay $750 million over the next five years to settle litigation with Israel’s tax authorities. The deal settles all pending disputes over the Israel-based company’s taxes payable...
View ArticleAmgen calls Colorado's price controls on Enbrel 'unconstitutional'
Amgen on Monday called on a Colorado federal court to overturn the state drug affordability board’s decision to cap the price of Amgen’s blockbuster biologic Enbrel. The California-based company said...
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Q&A: FDA medical policy chief talks decentralized trial guidance, improving...
The FDA’s director of its Office of Medical Policy wants trial sponsors to keep participant experiences top-of-mind in their decentralized designs. Endpoints News sat down with Khair ElZarrad last week...
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Can CRISPR be given twice? Small study from Intellia suggests it can
A small trial exploring what happens when patients were given a second infusion of an experimental CRISPR therapy suggests that it could be safe to readminister, opening the door to treating conditions...
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Lilly becomes the latest pharma to tap OpenAI for help, this time for...
First it was Moderna, then Sanofi, and now Lilly. OpenAI’s influence on the pharmaceutical industry has made its way to Indianapolis. Diogo Rau Lilly Chief Information Officer Diogo Rau said Tuesday...
View ArticleArrowhead shelves one cardiometabolic drug candidate, focuses on another
On Tuesday, Arrowhead Pharmaceuticals said it will shift focus to its experimental cardiometabolic drug plozasiran and will deprioritize its work on zodasiran, emphasizing the need to be thoughtful...
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Lyell reports patient death, early responses in solid tumor CAR-T trial
In an early-stage clinical trial with a handful of patients, Lyell Immunopharma’s experimental CAR-T therapy for solid tumor cancers showed hints of efficacy but also faced significant safety concerns,...
View ArticleZealand rides obesity wave with $1B raise to advance amylin drug and look for...
Zealand Pharma is raising $1 billion to focus on its “crown jewel” — an amylin analog for weight loss — both to advance it into a Phase 2b trial and hunt for a development and commercial partner. CEO...
View ArticleAlexis Borisy and Zach Weinberg's Curie.Bio secures $380M to support...
Curie.Bio, a Cambridge, MA-based biotech accelerator that aims to “free the founders,” has raised a $380 million fund mainly to support nascent startups that graduate from its program. The fund,...
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With a $372M megaround, Formation Bio looks to in-license 10+ drugs
While the bulk of AI-focused biotechs try to discover drugs and push the boundaries of biology, Benjamine Liu would rather synthesize meeting minutes than molecules. Liu’s startup, Formation Bio, is...
View ArticleModerna's updated RSV vaccine disappoints with only 50% efficacy
Moderna reported that its vaccine was 50% effective at preventing lower respiratory disease following RSV infection, falling short of numbers reported by GSK and Pfizer heading into the fall, when...
View ArticleTaysha’s $75M offering; Augustine raises €17M
Plus, news about Agile Therapeutics, Insud, Werewolf Therapeutics and Allakos: Taysha Gene Therapies sells $75M in shares: The biotech is issuing more than 14 million shares of common stock for $2.25...
View ArticleFDA publishes long-awaited guidance on clinical trial diversity
As the White House kicked off a public forum on clinical trials on Wednesday, the FDA simultaneously published a delayed draft guidance on ensuring clinical trials become diverse. The draft guidance...
View ArticleNovo Nordisk takes $816M impairment loss after Phase 3 fail in chronic kidney...
Novo Nordisk said Wednesday morning a small molecule that it recently bought for up to $1.3 billion has failed a Phase 3 trial in chronic kidney disease. The Danish drugmaker said it will take an...
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Savara’s rare lung disease treatment passes Phase 3
Savara reported that its daily treatment for a rare lung disease met the primary endpoint in a key late-stage study. The company is developing molgramostim for autoimmune pulmonary alveolar proteinosis...
View ArticleEMA calls for member states to lend a hand to ease GLP-1 supply bottlenecks
The European Medicines Agency is calling for both pharma companies and its member states to address the supply pressures on GLP-1 weight loss and diabetes drugs. The ongoing shortage for GLP-1 drugs is...
View ArticleHHS reveals 64 drugs up for Medicare inflation rebates next quarter
More drugs than ever will be subject to Medicare inflation rebates under the Inflation Reduction Act next quarter. On Wednesday, the Department of Health and Human Services revealed the 64 drugs that...
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Scientists unveil new way to make large changes to genes, and no CRISPR is...
Scientists led by Patrick Hsu at the Arc Institute in Palo Alto have unveiled a new form of gene editing that can add, remove or flip large stretches of DNA — all without the help of CRISPR. CRISPR...
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Optum Rx may enter biosimilar market to match competitors CVS, Express Scripts
Top PBM Optum Rx may be moving into the biosimilar business, joining its competitors CVS and Express Scripts, according to a US trademark application for a business called Nuvaila. The application to...
View ArticleHaleon to sell nicotine replacement therapy business to Dr. Reddy’s for $630M
Haleon has agreed to sell its ex-US nicotine replacement therapy business to Dr. Reddy’s for a total of £500 million, or about $630 million, the company announced Wednesday. Under the deal, Haleon will...
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